Permeability Measurements of Unitary dose (and other) blister packs
 
InstrumentstestingSensorsGasses and vapoursConsultancy

 

About Versaperm

Versaperm manufactures gas permeability testing equipment, offers a comprehensive permeability testing service and a materials consultancy. These are used to measure gas permeability and leakage, important in medical and pharmaceutical packaging, foils and films, coatings, food and confectionery packaging and contents, and many other applications.

Instruments

Versaperm designs and manufactures instruments to meet each customer’s needs. Instruments are typically be based on a modular MkVI design.

Testing Service


Our laboratory testing service has over 30 years experience to enable us to choose the best technique to measure your sample's permeability both quickly and accurately.

 

Sensors

Our diverse and growing range of sensors are based on fundamentally different and divergent physical principals. The choice of the right sensor for an application is critical in the successful deployment of the equipment. We are not tied to a sensor manufacturer.

Gases / Vapours

At Versaperm we can measure the permeability for almost any gas / vapour including water vapour, Oxygen, CO2 Hydrogen, Helium, Nitrogen and Hydrocarbons.

Applications

Consultancy

Our Consultancy division combines our theoretical and practical Permeability skills in instrument design and manufacture. Permeability Consultancy

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Permeability Measurements of Unitary dose (and other) blister packs

Permeability measurements of blister packaging against water vapour and variety of gases can be produced quickly and accurately with out Mark VI Permeability measurement equipment.

Water vapour is the single most damaging contaminant. for blister packaging. The equipment can measure the permeability of both flat samples of the polymer (and foil) used as well as the finished blister. This is particularly important as the mechanical formation of the blister reduce the permeability of the polymer to a quarter of its initial value.

Blister Pack Permeability Measurement

Both the loss or gain of water can have potentially significant effects to the products within blister packs. Water loss may lead to a change in the physical properties of a solid preparation, or a change in viscosity and concentration of vital components in liquid products. Water gain can cause sensitive ingredients to swell. Powders intended for inhalation are particularly sensitive as their particle size is critical for correct delivery - and is significantly influenced by the moisture content.

For companies where the throughput for the permeability measurements of blister packaging is not high enough to warrant dedicated equipment, we also provide a laboratory testing service.

Gas Permeability of Polymers

Plastic

Parmachor values

Permeability (cc.20μ/m2.24h.atm)

Real values

N<sub>2</sub>

O2

CO2

PVA

160

0.02

0.06

0.21

0.2

PVCD

97

0.6

3.6

12

2

PET

68

21

80

310

40

PVC

61

100

200

1000

300

HDPE

39

800

2000

12000

2500

PP

31

1600

5400

20000

3000

PS

27

2400

8000

26000

/

LDPE

26

3200

10000

36000

10000

Blister packaging for pharmaceutical  tablets, capsules, lozenges and other products

Blister Packaging provides a barrier protection against contamination, particularly water vapour, for shelf life, drug efficacy as well as a degree of  tamper resistance.

Blister packaging incorporates a foil layer with an outer polymer layer  for each blister cavity.  The permeability of the blister pack is largely determined by the material and forming of the polymer.

Unitary Dose Blister pack Permeability

Click here for a press release on Blister Pack permeability testing

Click here for an unitary dose blister pack article on Wikipedia

Click here for an article on the use and permeability measurements of plastics and related materials for pharmaceutical and medical packaging


Versaperm Limited
10 Rawcliffe House, Howarth Road, Maidenhead, Berkshire, SL6 1AP, UK, Tel: +44 1628 777668
e.mail: webcontact@versaperm.com
© Versaperm Limited 2010